Benzenamine, N,3-dimethyl- → 2'-Methyl-N-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(3-methylphenyl)-1,1'-biphenyl-4-carboxamide

HRID 131677Notes

Reaction equation

HRID 131677 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=1.[CH3:23][NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[CH:26]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([N:24]([CH3:23])[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[CH:26]=2)=[O:22])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 69675Benzenamine, N,3-dimethyl-HCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Product 1

HCID 102721362'-Methyl-N-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(3-methylphenyl)-1,1'-biphenyl-4-carboxamide

Procedure

2′-Methyl-N-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(3-methylphenyl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and N-methyl-N-(3-methylphenyl)amine using method M. NMR; δH [2H6]—DMSO 7.85,(1H, dd), 7.64,(1H, d), 7.49,(1H, d), 7.34,(2H, d), 7.25,(2H, d), 7.15,(1H, t), 7.04,(1H, s), 7.00-6.94,(2H, m), 3.38,(3H, s), 2.55,(3H, s), 2.20,(3H, s), 2.19,(3H, s). LCMS; retention time 3.50 min, MH+ 398.

Sources & evidence

ORD record
ord-d88f2f7d5a4145fab1f59ee32e05a79e
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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