4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid → HCID 10225261, compound

HRID 131679Notes

Reaction equation

HRID 131679 reaction equation
CC1[O:6]C(C2C=C(C(N)=O)C=CC=2C2C=CC=CC=2)=NN=1.[CH3:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:30][C:31]([CH3:34])=[N:32][N:33]=2)=[CH:25][C:24]=1[C:35]1[CH:40]=[CH:39][C:38]([C:41](O)=[O:42])=[CH:37][CH:36]=1.[CH3:44][N-:45][CH2:46][C:47]1[CH:52]=[CH:51][C:50]([CH2:53][NH2:54])=[CH:49][CH:48]=1>>[CH3:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:30][C:31]([CH3:34])=[N:32][N:33]=2)=[CH:25][C:24]=1[C:35]1[CH:40]=[CH:39][C:38]([C:41]([NH:54][CH2:53][C:50]2[CH:51]=[CH:52][C:47]([C:46]([NH:45][CH3:44])=[O:6])=[CH:48][CH:49]=2)=[O:42])=[CH:37][CH:36]=1

Participants

4

Reactant 3

HCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic AcidHCID 54694430HCID 54694430, compoundHCID 131726920HCID 131726920, compound

Product 1

HCID 10225261HCID 10225261, compound

Procedure

2′-Methyl-N-4-[(methylamino)carbonyl]benzyl)5′-(5-methyl-1,3,4-oxadiazol-2-yl-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and N-methyl-(4-aminomethylbenzyl)amide using method H. NMR; δH [2H6]—DMSO 9.18,(1H, t), 8.38,(1H, q), 8.01,(2H, d), 7.89, (1H, dd), 7.78,(3H, m), 7.54,(3H, m), 7.40,(2H, d), 4.55,(2H, d), 2.76,(3H, d), 2.56,(3H, s), 2.31,(3H, s). LCMS; retention time 2.88 min, MH+ 441.

Sources & evidence

ORD record
ord-03dde4b34e6446e79c25ca58e083c3fb
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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