4-Methylbenzylamine → HCID 69218562, compound

HRID 131688Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=1.[CH3:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([NH:29][CH2:28][C:27]2[CH:30]=[CH:31][C:24]([CH3:23])=[CH:25][CH:26]=2)=[O:22])=[CH:18][CH:19]=1

Participants

Reactant 2

HCID 660354-Methylbenzylamine

HCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Product 1

HCID 69218562HCID 69218562, compound

Procedure

2′-Methyl-N-(4-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 4-methylbenzylamine using method N. NMR; δH [2H6]—DMSO 9.10,(1H, t), 7.99,(2H, d), 7.89,(1H, dd), 7.76,(1H, d), 7.56-7.51,(3H, m), 7.22,(2H, d), 7.13,(2H, d), 4.46,(2H, d), 2.56,(3H, s), 2.31,(3H, s), 2.27,(3H, s). LCMS; retention time 3.48 min, MH+ 398.

Sources & evidence

ORD record: ord-bc074fbfbb7d45fb9d6ada1989428733
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384963B2

Reaction notes

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