Methyl iodide → HCID 10113330, compound

HRID 131698Notes

Reaction equation

HRID 131698 reaction equation
[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][NH:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[C:21]([C:23]4[O:24][C:25]([CH3:28])=[N:26][N:27]=4)[CH:20]=[CH:19][C:18]=3[CH3:29])=[CH:13][CH:12]=2)=[O:10])=[CH:5][CH:4]=1.I[CH3:33]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]([CH3:33])[C:9]([C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:22]=[C:21]([C:23]4[O:24][C:25]([CH3:28])=[N:26][N:27]=4)[CH:20]=[CH:19][C:18]=3[CH3:29])=[CH:15][CH:16]=2)=[O:10])=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10158653HCID 10158653, compound

Product 1

HCID 10113330HCID 10113330, compound

Procedure

N-(4-Methoxybenzyl)-N-methyl-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from N-(4-methoxybenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodomethane using method L. NMR; δH [2H6]—DMSO 7.89,(1H. d), 7.75,(1H, s), 7.55-7.47,(5H, m), 7.30,(1H, m), 7.13,(1H, m), 6.94,(2H, d), 4.62-4.46,(2H, m), 3.74,(3H, s), 2.85,(3H, b), 2.55,(3H, s), 2.31,(3H, s). LCMS; retention time 3.46 min, MH+ 428.

Sources & evidence

ORD record
ord-c6a2582ef2a4412caf258973a6378d07
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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