反应详情

1-(4-Fluorophenyl)-5-methoxy-1H-indazole (137e, 1.0 mmol, 242 mg) was dissolved in dichloromethane (4 ml) and BBr3 (4 ml, 1 M in dichloromethane) was added. The reaction mixture was stirred in r.t. overnight before it was quenched with water (20 ml). The product was extracted with dichloromethane (2×20 ml) and washed with sat. NaHCO3. The organic phase was dried over Na2SO4, concentrated and purified by flash chromatography on silica gel (heptane-ethyl acetate).

1. customwas quenched with water (20 ml)
2. extractionThe product was extracted with dichloromethane (2×20 ml)
3. washwashed with sat. NaHCO3
4. dry with materialThe organic phase was dried over Na2SO4
5. concentrationconcentrated
6. custompurified by flash chromatography on silica gel (heptane-ethyl acetate)