Methyl iodide → HCID 10223343, compound

HRID 131701Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)=[O:21])=[CH:16][CH:15]=1.I[CH3:32]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([N:22]([CH3:32])[CH2:23][C:24]2[CH:25]=[CH:26][C:27]([CH3:30])=[CH:28][CH:29]=2)=[O:21])=[CH:16][CH:15]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 69218562HCID 69218562, compound

Product 1

HCID 10223343HCID 10223343, compound

Procedure

2′-Methyl-N-methyl-N-(4-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4carboxamide was prepared from 2′-methyl-N-(4-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodomethane using method L. NMR; δH [2H6]—DMSO 7.88,(1H, d), 7.75,(1H, s), 7.55-7.47,(5H, m), 7.25-7.08,(4H, m), 4.65-4.49,(2H, m), 2.88,(3H, m), 2.55,(3H, s), 2.32,(6H, m). LCMS; retention time 3.60 min, MH+ 412.

Sources & evidence

ORD record: ord-afc9d478b574441294319b69987de99e
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384963B2

Reaction notes

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