2-Chlorobenzylamine → HCID 10223738, compound

HRID 131704Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[Cl:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26][NH2:27]>>[Cl:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26][NH:27][C:20]([C:17]1[CH:16]=[CH:15][C:14]([C:3]2[CH:4]=[C:5]([C:8]3[O:9][C:10]([CH3:13])=[N:11][N:12]=3)[CH:6]=[CH:7][C:2]=2[CH3:1])=[CH:19][CH:18]=1)=[O:21]

Participants

Reactant 2

HCID 666482-Chlorobenzylamine

HCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Product 1

HCID 10223738HCID 10223738, compound

Procedure

N-(2-Chlorobenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 2-chlorobenzylamine using method N. NMR; δH [2H6]—DMSO 9.15,(1H, t), 8.03,(2H, d), 7.90,(1H, dd), 7.77,(1H, d), 7.56-7.53,(3H, m), 7.47,(1H, m), 7.39,(1H, m), 7.35-7.28,(2H, m), 4.57,(2H, d), 2.56,(3H, s), LCMS; retention time 3.53 min, MH+ 418/420.

Sources & evidence

ORD record: ord-b0b105e7496a416fa71b02fb3373a85a
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384963B2

Reaction notes

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