Benzenemethanamine, 3-chloro- → HCID 10136758, compound

HRID 131709Notes

Reaction equation

HRID 131709 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=1.[Cl:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH2:27][NH2:28]>>[Cl:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH2:27][NH:28][C:20]([C:17]1[CH:16]=[CH:15][C:14]([C:3]2[CH:4]=[C:5]([C:8]3[O:9][C:10]([CH3:13])=[N:11][N:12]=3)[CH:6]=[CH:7][C:2]=2[CH3:1])=[CH:19][CH:18]=1)=[O:22]

Participants

3

Reactant 2

HCID 77802Benzenemethanamine, 3-chloro-HCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Product 1

HCID 10136758HCID 10136758, compound

Procedure

N-(3-Chlorobenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 3-chlorobenzylamine using method N. NMR; δH [2H6]—DMSO 9.19,(1H, t), 8.00,(2H, t), 7.90,(1H, dd), 7.77,(1H, d), 7.56-7.52,(3H, m), 7.39-7.29,(4H, m), 4.51,(2H, d), 2.56,(3H, s), 2.31,(3H, s). LCMS; retention time 3.56 min, MH+ 418/420.

Sources & evidence

ORD record
ord-ecf07b24a6d44e56ace63df0cf1e611b
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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