N-(4-Aminophenyl)-4-methylbenzenesulfonamide → HCID 10119591, compound

HRID 131719Notes

Reaction equation

HRID 131719 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[C:23]1([CH3:40])[CH:28]=[CH:27][C:26]([S:29]([NH:32][C:33]2[CH:39]=[CH:38][C:36]([NH2:37])=[CH:35][CH:34]=2)(=[O:31])=[O:30])=[CH:25][CH:24]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:37][C:36]2[CH:35]=[CH:34][C:33]([NH:32][S:29]([C:26]3[CH:27]=[CH:28][C:23]([CH3:40])=[CH:24][CH:25]=3)(=[O:31])=[O:30])=[CH:39][CH:38]=2)=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 458884N-(4-Aminophenyl)-4-methylbenzenesulfonamideHCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Product 1

HCID 10119591HCID 10119591, compound

Procedure

2′-Methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-N-[4-(p-toluenesulphonamido)phenyl]-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 4-(p-toluenesulphonamido)aniline using method I. NMR; δH [2H6]—DMSO 10.26,(1H, s), 10.08,(1H, b), 8.01,(2H, d), 7.90,(1H, dd), 7.77,(1H, d), 7.63,(4H, m), 7.56,(3H, m), 7.33,(2H, d), 7.06,(2H, d), 2.56,(3H, s), 2.33-2.32,(6H, m). LCMS; retention time 3.52 min, MH+ 539.

Sources & evidence

ORD record
ord-1a8f71eb1b80438faa22cb7f8091b00a
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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