Methyl iodide → N-(3-Methoxybenzyl)-N-methyl-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

HRID 131721Notes

Reaction equation

HRID 131721 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][NH:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[C:20]([C:22]3[O:23][C:24]([CH3:27])=[N:25][N:26]=3)[CH:19]=[CH:18][C:17]=2[CH3:28])=[CH:12][CH:11]=1)=[O:9].I[CH3:33]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]([CH3:33])[C:8]([C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[C:20]([C:22]3[O:23][C:24]([CH3:27])=[N:25][N:26]=3)[CH:19]=[CH:18][C:17]=2[CH3:28])=[CH:14][CH:15]=1)=[O:9]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10158652N-[(3-methoxyphenyl)methyl]-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide

Product 1

HCID 10159571N-(3-Methoxybenzyl)-N-methyl-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

Procedure

N-(3-Methoxybenzyl)-N-methyl-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from N-(3-methoxybenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodomethane using method L. NMR; δH [2H6]—DMSO 7.89,(1H, d), 7.76,(1H, b), 7.58-7.45,(5H, m), 7.30,(1H, t), 6.93-6.72,(3H, m), 4.67-4.51,(2H, m), 3.76,(3H, s), 2.92-2.89,(3H, m), 2.55,(3H, s), 2.32,(3H, s). LCMS; retention time 3.39 min, MH+ 428.

Sources & evidence

ORD record
ord-cdee1918f2b84c888eb1ae1ed0bd3508
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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