Methyl iodide → HCID 10181193, compound

HRID 131722Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][NH:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([C:21]3[O:22][C:23]([CH3:26])=[N:24][N:25]=3)[CH:18]=[CH:17][C:16]=2[CH3:27])=[CH:11][CH:10]=1)=[O:8].I[CH3:32]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]([CH3:32])[C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([C:21]3[O:22][C:23]([CH3:26])=[N:24][N:25]=3)[CH:18]=[CH:17][C:16]=2[CH3:27])=[CH:11][CH:10]=1)=[O:8]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 10136758HCID 10136758, compound

Product 1

HCID 10181193HCID 10181193, compound

Procedure

N-(3-Chlorobenzyl)-N-methyl-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from N-(3-chlorobenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodomethane using method L. NMR; δH [2H6]—DMSO 7.89,(1H, d), 7.76,(1H, b), 7.59-7.33,(8H, m), 7.23,(1H, b), 4.70-4.55,(2H, m), 2.92,(3H, s), 2.55,(3H, s), 2.32,(3H, s). LCMS; retention time 3.58 min, MH+ 432/434.

Sources & evidence

ORD record: ord-3fe8daf5db86436f872d287ae9e4816c
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384963B2

Reaction notes

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