Methyl iodide → HCID 10203071, compound

HRID 131724Notes

Reaction equation

[Cl:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[CH2:4][NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18]([C:20]3[O:21][C:22]([CH3:25])=[N:23][N:24]=3)[CH:17]=[CH:16][C:15]=2[CH3:26])=[CH:10][CH:9]=1)=[O:7].I[CH3:32]>>[Cl:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[CH2:4][N:5]([CH3:32])[C:6]([C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:19]=[C:18]([C:20]3[O:21][C:22]([CH3:25])=[N:23][N:24]=3)[CH:17]=[CH:16][C:15]=2[CH3:26])=[CH:12][CH:13]=1)=[O:7]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 10223738HCID 10223738, compound

Product 1

HCID 10203071HCID 10203071, compound

Procedure

N-(2-Chlorobenzyl)-N-methyl-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from N-(2-chlorobenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodomethane using method L. NMR; δH [2H6]—DMSO 7.89,(1H, d), 7.77,(1H, b), 7.62-7.33,(9H, m), 4.78-4.62,(2H, m), 2.95,(3H, s), 2.56,(3H, s), 2.33-2.29,(3H, m). LCMS; retention time 3.54 min, MH+ 432/434.

Sources & evidence

ORD record: ord-75f0413e23794bf081dfdadd6863a00e
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384963B2

Reaction notes

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