Methyl iodide → HCID 10160903, compound

HRID 131728Notes

Reaction equation

HRID 131728 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=[CH:26][CH:25]=2)=[O:21])=[CH:16][CH:15]=1.I[CH3:35]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([N:22]([CH3:35])[CH2:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=[CH:26][CH:25]=2)=[O:21])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 69221087HCID 69221087, compound

Product 1

HCID 10160903HCID 10160903, compound

Procedure

2′-Methyl-N-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(naphth-1-ylmethyl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(naphth-1-ylmethyl)-1,1′-biphenyl-4-carboxamide and iodomethane using method L. NMR; δH [2H6]—DMSO 8.17,(1H, d), 7.99-7.40,(13H, m), 5.19-5.05,(2H, m), 3.03,(1H, s), 2.85,(2H, s), 2.55,(3H, s), 2.32-2.23,(3H, m). LCMS; retention time 3.66 min, MH+ 448.

Sources & evidence

ORD record
ord-1e10344c23fb42d1a85c5fa06b460389
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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