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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1317291Generated: November 1, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1317291

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentCID 14794698HCID 14794698—
Catalyst1~4~,2~4~,3~4~-Tri-tert-butyl-1~2~,2~2~:2~6~,3~2~-terpyridineHCID 4229824—
CatalystHCID 178440864HCID 178440864—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-7e0a20d9aa184392a4684b394ca0a018
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions