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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1317501Generated: October 31, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1317501

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentCesium acetateHCID 5152919—
Catalyst1,10-Phenanthroline-5,6-dioneHCID 72810—
CatalystHCID 178440864HCID 178440864—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-bbea5233476440a79ad5a3513d20c98c
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions