Imidazole → HCID 55299320, compound

Participants

Reaction Steps

To a solution of imidazole (68 g, 1 mole) in ethyl acetate (1 L) in a 10-L container was added sodium bicarbonate (0.85 kg, 10 mole) and water (5 L) at ambient temperature. Under magnetic agitation, acetic anhydride (400 mL, 4.04 mole) was added dropwise over a course of 45 minutes. The resulting mixture was stirred overnight (12 hours). Then, the solid was filtered out, washed, and triturated (in 600 mL water) at 80° C. for 30 min. After filtration, the product was collected in 120 g (ca. 80%).

Provenance & Evidence