HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guaiacol → HCID 66999029, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guaiacol | HCID 460 | — |
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 1-Fluoro-4-methanesulfonyl-2-nitrobenzene | HCID 313137 | — |
| Reactant | 2-(2-Methoxyphenoxy)-5-(methylsulfonyl)aniline | HCID 43448157 | — |
| Product | N-[2-(2-Methoxyphenoxy)-5-(methylsulfonyl)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732998 | 65% |
| Product | HCID 66999029 | HCID 66999029 | 75% |
Reaction Steps
2-(2-Methoxyphenoxy)-5-(methylsulfonyl)-1-nitrobenzene (1.21 g, 75%) was prepared from 2-methoxyphenol (0.68 g, 5.5 mmol) and 1-fluoro-4-methylsulfonyl-2-nitrobenzene (1.09 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-methoxyphenoxy)-5-(methylsulfonyl)aniline (0.68 g, 62%) following general procedure B. N-[2-(2-Methoxyphenoxy)-5-(methylsulfonyl)phenyl]-N′-(thiazol-2-yl)urea (136 mg, 65%) was prepared from 2-(2-methoxyphenoxy)-5-(methylsulfonyl)aniline (146 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07384967B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-6db23ce90db7410eaf05c86682ab77d2 |
| Source note | uspto-grants-2008_06 |