2-Aminothiazole → N-[2-(2,3-Dimethoxyphenoxy)-5-methoxyphenyl]-N'-(thiazol-2-yl)urea

Participants

Role	Name	HCID	Charge
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	4-Chloro-3-nitroanisole	HCID 25140	—
Reactant	2,3-Dimethoxyphenol	HCID 78828	—
Reactant	2-(2,3-Dimethoxyphenoxy)-5-methoxyaniline	HCID 66998722	—
Product	N-[2-(2,3-Dimethoxyphenoxy)-5-methoxyphenyl]-N'-(thiazol-2-yl)urea	HCID 59732942	62%
Product	2-(2,3-Dimethoxyphenoxy)-5-methoxy-1-nitrobenzene	HCID 66998961	56%

Reaction Steps

2-(2,3-Dimethoxyphenoxy)-5-methoxy-1-nitrobenzene (0.85 g, 56%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 4-chloro-3-nitroanisole (0.94 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,3-dimethoxyphenoxy)-5-methoxyaniline (0.65 g, 85%) following general procedure C. N-[2-(2,3-Dimethoxyphenoxy)-5-methoxyphenyl]-N′-(thiazol-2-yl)urea (124 g, 62%) was prepared from 2-(2,3-dimethoxyphenoxy)-5-methoxyaniline (133 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07384967B2
Source dataset	uspto-grants-2008_06
ORD ID	ord-ecb097a327b3416588f028864be2c89e
Source note	uspto-grants-2008_06