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2-Aminothiazole → N-[2-(2,3-Dimethoxyphenoxy)pyridin-3-yl]-N'-(thiazol-2-yl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 反応物 | 2-Bromo-3-nitropyridine | HCID 555054 | — |
| 反応物 | 2-(2,3-Dimethoxyphenoxy)-3-aminopyridine | HCID 66998944 | — |
| 生成物 | N-[2-(2,3-Dimethoxyphenoxy)pyridin-3-yl]-N'-(thiazol-2-yl)urea | HCID 59732822 | 70% |
反応手順
2-(2,3-Dimethoxy)phenoxy-3-nitropyridine (1.03 g, 75%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2-bromo-3-nitropyridine (1.05 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2,3-dimethoxyphenoxy)-3-aminopyridine (0.57 g, 62%) following the general procedure B. N-[2-(2,3-Dimethoxyphenoxy)pyridin-3-yl]-N′-(thiazol-2-yl)urea (131 mg, 70%) was prepared from 2-(2,3-dimethoxyphenoxy)-3-aminopyridine (123 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-9ccc16c72bb04bafabb40a9644545b83 |
| 出典メモ | uspto-grants-2008_06 |