2-Aminothiazole → 2-(3,5-Dimethylphenylsulfanyl)nitrobenzene

Participants

Role	Name	HCID	Charge
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	1-Fluoro-2-nitrobenzene	HCID 73895	—
Reactant	3,5-Dimethylbenzenethiol	HCID 117548	—
Reactant	2-((3,5-Dimethylphenyl)thio)aniline	HCID 66998967	—
Product	N-[2-(3,5-Dimethylphenylsulfanyl)phenyl]-N'-(thiazol-2-yl)urea	HCID 59733126	74%
Product	2-(3,5-Dimethylphenylsulfanyl)nitrobenzene	HCID 66999017	78%

Reaction Steps

2-(3,5-Dimethylphenylsulfanyl)nitrobenzene (1.01 g, 78%) was prepared from 3,5-dimethylthiophenol (0.76 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(3,5-dimethylphenylsulfanyl)aniline (0.64 g, 72%) following the general procedure B. N-[2-(3,5-Dimethylphenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (131 mg, 74%) was prepared from 2-(3,5-dimethylphenylsulfanyl)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07384967B2
Source dataset	uspto-grants-2008_06
ORD ID	ord-e41ede9e832c434b94b3d4104ebcbf1e
Source note	uspto-grants-2008_06