HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(2-Methoxyphenylsulfanyl)nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Thioguaiacol | HCID 23642 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 2-(2-Methoxyphenylsulfanyl)aniline | HCID 20980631 | — |
| Product | 2-(2-Methoxyphenylsulfanyl)nitrobenzene | HCID 824907 | 82% |
| Product | N-[2-(2-Methoxyphenylsulfanyl)phenyl]-N'-(thiazol-2-yl)urea | HCID 59733084 | 62% |
Reaction Steps
2-(2-Methoxyphenylsulfanyl)nitrobenzene (1.07 g, 82%) was prepared from 2-methoxy thiophenol (0.76 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-methoxyphenylsulfanyl)aniline (0.66 g, 70%) following general procedure B. N-[2-(2-Methoxyphenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (110 mg, 62%) was prepared from 2-(2-methoxyphenylsulfanyl)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07384967B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-e67c8779f6fe4457b8596b100dca7ece |
| Source note | uspto-grants-2008_06 |