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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 131983Generated: October 29, 2026

(2-Amino-5-methyl-phenyl)-cyclopropyl-methanone → (2-Amino-5-methyl-phenyl)-cyclobutyl-methanone

https://huagongshe.com/reaction/131983

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Amino-5-methyl-phenyl)-cyclopropyl-methanoneHCID 15346381—
ReactantN-methoxy-N-methylcyclobutanecarboxamideHCID 45084194—
Product(2-Amino-5-methyl-phenyl)-cyclobutyl-methanoneHCID 6699916280%

Reaction Steps

Crude (2-amino-5-methyl-phenyl)-cyclobutyl-methanone (80%, oil) was prepared in a similar fashion as described for (2-amino-5-methyl-phenyl)-cyclopropyl-methanone using cyclobutanecarboxylic acid methoxy-methyl-amide instead of cyclopropanecarboxylic acid methoxy-methyl-amide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07384967B2
Source datasetuspto-grants-2008_06
ORD IDord-0b51051691c4464f8a178f4c282f61e6
Source noteuspto-grants-2008_06