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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1320013Generated: October 29, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1320013

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentCID 14794698HCID 14794698—
Catalyst2,2'-BIPYRIDINE-5,5'-DICARBONITRILEHCID 11052781—
CatalystHCID 178486303HCID 178486303—
SolventDimethyl SulfoxideHCID 679—
SolventM-XyleneHCID 7929—
SolventHCID 178504073HCID 178504073—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-a81b6f14658b48b393b7e06f85442458
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions