Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 1h-Pyrazole-3-carboxamide,4-[3-(hydroxymethyl)phenyl]-1-[(4-methoxyphenyl)methyl]-n-phenyl- | HCID 66855422 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 178521930 | HCID 178521930 | 35.2% |
Reaction Steps
A mixture of 4-(3-hydroxymethyl-phenyl)-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid phenylamide (20 mg) and anisole (20 μl) in trifluoroacetic acid (1 ml) was heated at 120° C. (50 W) for 15 minutes in a CEM Discover microwave synthesiser. The reaction was evaporated then purified by flash column chromatography eluting with 2:1 ethyl acetate/hexane. Product containing fractions were combined and evaporated to give 5 mg of product. (LC/MS: Rt 2.55 [M+H]+294).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07385059B2 |
|---|
| Source dataset | uspto-grants-2008_06 |
|---|
| ORD ID | ord-685b1dd45da14f468377f574b50c1337 |
|---|
| Source note | uspto-grants-2008_06 |
|---|
