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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1320917Generated: November 1, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1320917

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentCesium acetateHCID 5152919—
CatalystHCID 178486303HCID 178486303—
CatalystHCID 178512253HCID 178512253—
SolventDimethyl SulfoxideHCID 679—
SolventM-XyleneHCID 7929—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-6877eb88c13f4d9dad1ab0e10306ff68
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions