Hydrochloric Acid → HCID 178440827, compound

Participants

Reaction Steps

Tert-butyl 5-(3-tert-butylphenyl)-4,5,6,7-tetrahydro-2H-indazol-5-ylcarbamate (499 mg, 1.35 mmol) was taken up in 2 mL of dioxane followed by the addition of HCl (3.38 mL of a 4N solution in dioxane). The reaction was stirred for 4 h and then concentrated to yield 350 mg (96% yield) of a white solid. 1H-NMR (CD3OD) δ8.17 (d, J=2.7 Hz, 1H), 7.60 (s, 1H), 7.52-7.45 (m, 1H), 7.44-7.32 (m, 2H), 3.77 (d, J=14.8 Hz, 1H), 3.21 (d, J=14.8 Hz, 1H), 3.10-2.94 (m, 1H), 2.82-2.66 (m, 1H), 2.59-2.42 (m, 2H), 1.30 (s, 9H); retention time (min)=1.70 (method [8]); MS (ESI) 253.3.

Provenance & Evidence