Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1321237Generated: October 28, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1321237

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentCID 14794698HCID 14794698—
CatalystHCID 178486303HCID 178486303—
SolventDimethyl SulfoxideHCID 679—
SolventM-XyleneHCID 7929—
SolventHCID 178504073HCID 178504073—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100.99%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-5acb93524dfa4bed97b5e0e4470a9aba
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions