Pivaloyl chloride → HCID 59339657, compound

HRID 13213Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:8]([O:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[N:18]([C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)[N:17]=[CH:16]2)[C@@H:9]([NH2:11])[CH3:10].[C:29](Cl)(=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:8]([O:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[N:18]([C:22]1[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=1)[N:17]=[CH:16]2)[C@@H:9]([NH:11][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])[CH3:10]

Participants

Reactant 2

HCID 62493Pivaloyl chloride

HCID 59339806HCID 59339806, compound

Product 1

HCID 59339657HCID 59339657, compound

Procedure

Prepared as described in Example 1 using (1R,2S)-1-(2-chlorophenyl)-1-(1-(4-fluorophenyl) 1H-indazol-5-yloxy)propan-2-amine (300a, 18 mg, 0.05 mmol) and Pivaloyl chloride (17 μl, 0.14 mmol). Yield 22 mg (100%).

Workup

customPrepared

Sources & evidence

ORD record: ord-56c1d21c8c5a4e6c9ac3b0f327d9afb0
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07728030B2

Reaction notes

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