HRID132138

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cccc(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)OCc2ccccc2)CN2CCc3cc(F)ccc32)c1

HCID11192417

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：Cc1cccc(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)CN2CCc3cc(F)ccc32)c1

HCID11386148

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The title compound of Example 42 (200 mg, 0.348 mmol) and 10% Pd/C were treated with MeOH (2 mL) and the atmosphere in the reaction was switched to hydrogen. After stirring overnight, the atmosphere in the reaction was switched back to nitrogen and the reaction was filtered through celite. Removal of solvent and drying afforded a white solid (168 mg, 94); HPLC-MS calcd. for C27H34FN3O4 (M+H+) 484.3, found 484.4.

WORKUP

后处理

filtrationthe reaction was filtered through celite
customRemoval of solvent
customdrying
customafforded a white solid (168 mg, 94)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-75daac9e37ae4b838e748bac9087390b
来源数据集: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07384970B2
来源说明: uspto-grants-2008_06

反应 SMILES

C([O:8][C:9](=[O:42])[CH2:10][CH2:11][C@H:12]([NH:24][C:25](=[O:41])[C@@H:26]([NH:31][C:32](=[O:40])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([CH3:39])[CH:34]=1)[CH2:27][CH:28]([CH3:30])[CH3:29])[CH2:13][N:14]1[C:22]2[C:17](=[CH:18][C:19]([F:23])=[CH:20][CH:21]=2)[CH2:16][CH2:15]1)C1C=CC=CC=1.[H][H]>[Pd].CO>[F:23][C:19]1[CH:18]=[C:17]2[C:22](=[CH:21][CH:20]=1)[N:14]([CH2:13][C@@H:12]([NH:24][C:25](=[O:41])[C@@H:26]([NH:31][C:32](=[O:40])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([CH3:39])[CH:34]=1)[CH2:27][CH:28]([CH3:30])[CH3:29])[CH2:11][CH2:10][C:9]([OH:42])=[O:8])[CH2:15][CH2:16]2