HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 60131304, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid | HCID 14158015 | — |
| Reactant | HCID 59733160 | HCID 59733160 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 60131304 | HCID 60131304 | — |
Reaction Steps
(S)—N-(4-trifluoromethoxy-phenyl)-propane-1,2-diamine (76.7 mg, 0.328 mmol), (S)-2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid (100 mg, 0.328 mmol) and HATU (125 mg, 0.328 mmol) were added to a round bottom flask with 20 mL of dry DCM. DIPEA (127 mg, 0.982 mmol) was added dropwise over three minutes with vigorous stirring. The resulting slurry was stirred for 1.5 hours. The solution was then washed with sodium bicarbonate, the organic layer was separated and partially concentrated and the concentrate was purified by flash chromatography. Yield 138 mg, 81%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07384970B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-4ebee6704a384ae2b1c35f9d64880a11 |
| Source note | uspto-grants-2008_06 |