Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1321739Generated: October 30, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1321739

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentCesium acetateHCID 5152919—
Catalyst2,2':6',2''-TerpyridineHCID 70848—
CatalystHCID 178461822HCID 178461822—
SolventDimethyl SulfoxideHCID 679—
SolventM-XyleneHCID 7929—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-668f8c84a5204a89b92b42bff702fd98
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions