1-(4-fluorophenyl)-5-iodo-1H-indazole → HCID 59339867, compound

HRID 13218Notes

Reaction equation

HRID 13218 reaction equation
[Cl-].[F:2][C:3]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:4]=1[O:5][CH2:6][C@@H:7]([OH:11])[C@@H:8]([NH3+:10])[CH3:9].[F:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[C:32]3[C:27](=[CH:28][C:29](I)=[CH:30][CH:31]=3)[CH:26]=[N:25]2)=[CH:20][CH:19]=1>>[F:2][C:3]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:4]=1[O:5][CH2:6][C@@H:7]([O:11][C:29]1[CH:28]=[C:27]2[C:32](=[CH:31][CH:30]=1)[N:24]([C:21]1[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=1)[N:25]=[CH:26]2)[C@@H:8]([NH2:10])[CH3:9]

Participants

3

Reactant 2

HCID 592511281-(4-fluorophenyl)-5-iodo-1H-indazoleHCID 66812663HCID 66812663, compound

Product 1

HCID 59339867HCID 59339867, compound

Procedure

Prepared as described in Example 1a from (2S,3S)-4-(2,4-difluorophenoxy)-3-hydroxybutan-2-aminium chloride (290 mg, 1.14 mmol) and 1-(4-fluorophenyl)-5-iodo-1H-indazole (464 mg, 1.37 mmol). Yield: 90 mg (18%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2c9940d6bdc74368be367b36b15d4f91
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

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