HCID 59732028, compound → HCID 59732022, compound

HRID 132183Notes

Reaction equation

[NH2:1][C@H:2]1[C:8](=[O:9])[N:7]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:6][C:5]2[C:17]([CH3:29])=[C:18]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH:19]=[CH:20][C:4]=2[CH2:3]1.C(N1C(=O)[C@H](N[C:46]([N:48]2[CH2:53][CH2:52][CH:51]([N:54]3[CH2:63][C:62]4[C:57](=[CH:58][CH:59]=[CH:60][CH:61]=4)[NH:56][C:55]3=[O:64])[CH2:50][CH2:49]2)=[O:47])CC2C=C(C)C(NC(=O)OC(C)(C)C)=CC=2C1)C1C=CC=CC=1>>[CH2:10]([N:7]1[C:8](=[O:9])[C@H:2]([NH:1][C:46]([N:48]2[CH2:53][CH2:52][CH:51]([N:54]3[CH2:63][C:62]4[C:57](=[CH:58][CH:59]=[CH:60][CH:61]=4)[NH:56][C:55]3=[O:64])[CH2:50][CH2:49]2)=[O:47])[CH2:3][C:4]2[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[C:17]([CH3:29])[C:5]=2[CH2:6]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 59732028HCID 59732028, compound

HCID 59732044HCID 59732044, compound

Product 1

HCID 59732022HCID 59732022, compoundYield 94%

Procedure

(R)-tert-Butyl 4-amino-2-benzyl-9-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-ylcarbamate was reacted in a manner analogous to the preparation of (R)-tert-butyl 2-benzyl-7-methyl-3-oxo-4-(4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamido)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-ylcarbamate. Title compound was obtained as off-white solid in 94% yield.

Sources & evidence

ORD record: ord-f5f45107ba49435f872fb740a3f94c41
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384930B2

Reaction notes

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