反应详情

tert-Butyl 4-(5-hydroxy-3-phenyl-4,5-dihydroisoxazol-5-yl)piperidine-1-carboxylate (320 mg, 0.92 mmol) was dissolved in methanol (10 mL). A solution of sodium carbonate (200 mg, 1.9 mmol) in water (10 mL) was added to the mixture. Reaction was stirred at reflux for 2 hours. Methanol was removed from the reaction mixture in vacuo. Remaining aqueous was extracted 2× ethyl acetate. Combined extracts were washed with brine. Organic layer was dried (magnesium sulfate), filtered, and concentrated. Title compound was obtained as off-white solid in 86% yield. (M−C4H8+H)+=273.1.

1. customReaction
2. temperatureat reflux for 2 hours
3. customMethanol was removed from the reaction mixture in vacuo
4. extractionRemaining aqueous was extracted 2× ethyl acetate
5. washCombined extracts were washed with brine
6. dry with materialOrganic layer was dried (magnesium sulfate)
7. filtrationfiltered
8. concentrationconcentrated