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alpha-Bromo-2-nitrotoluene → tert-Butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperazine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | alpha-Bromo-2-nitrotoluene | HCID 77569 | — |
| 反応物 | Tert-butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate | HCID 46785870 | — |
| 反応物 | Tert-butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperidine-1-carboxylate | HCID 59732041 | — |
| 生成物 | tert-Butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperazine-1-carboxylate | HCID 59732018 | 51% |
反応手順
tert-Butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate (1.0 g, 3.9 mmol) and 2-nitrobenzylbromide (1.0 g, 4.6 mmol) were reacted in a manner analogous to the preparation of tert-butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperidine-1-carboxylate. Title compound was obtained as amber oil in 51% yield. MS m/e (M+H)+=394.4.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384930B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-3b2dc3ebc34e4e8ba164868d00eb64e8 |
| 出典メモ | uspto-grants-2008_06 |