化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | t-Butyl (1R,2R)-1-(2,3-dihydrobenzofuran-6-yl)-1-hydroxypropan-2-ylcarbamate | HCID 59339796 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | 98% |
| 生成物 | (1R,2R)-2-amino-1-(2,3-dihydrobenzofuran-6-yl)propan-1-ol | HCID 66812942 | — |
反応手順
t-Butyl (1R,2R)-1-(2,3-dihydrobenzofuran-6-yl)-1-hydroxypropan-2-ylcarbamate (1.58 g, 5.39 mmol) was stirred in a solution of HCl in EtOAc (1M, 20 ml) at 60° C. for 2 h. After cooling the solid precipitate was filtered and dried to afford the subtitle compound as hydrochloride (1.22 g, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728030B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-50ed7038747b4b8da7d3167b5e6c208b |
| 出典メモ | uspto-grants-2010_06 |