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HRID132279

反应详情

EQUATION

反应方程式

HRID 132279 的结构方程式

REACTANTS

反应物

2
结构：O=C1Nc2ccccc2CN1C1CCNCC1
HCID11042597

3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

C13H17N3O

结构：CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O
HCID68826479

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)CN1Cc2c(ccc3[nH]ncc23)C[C@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O
HCID59731961

未命名化合物

收率 32%

PROCEDURE

实验过程

[9-(2,2-dimethyl-propyl)-8-oxo-3,6,7,8,9,10-hexahydro-2,3,9-triaza-(R)-cyclohepta[e]inden-7-yl]-acetic acid (75 mg, 0.23 mmol) and 4-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl) piperidine (65 mg, 0.28 mmol) were combined in a manner analogous to the preparation of 4-Chloro-9-(2,2-dimethyl-propyl)-7-(R)-{2-oxo-2-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-ethyl}-6,7,9,10-tetrahydro-3H-2,3,9-triaza-cyclohepta[e]inden-8-one. Title compound was obtained as a white solid in 32% yield. High resolution MS m/e (M+H)+=543.3084.