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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1323027Generated: October 30, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1323027

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-iodo-4-(trifluoromethyl)-HCID 67993—
ReagentHCID 14574551HCID 14574551—
Catalyst2-(2,6-Dimethylphenylamino)-2-oxoacetic acidHCID 14987869—
CatalystHCID 178420723HCID 178420723—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-ba403f8b19b4494f81af5ec7cbc29bba
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions