Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
alpha-Bromo-2-nitrotoluene → tert-Butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | alpha-Bromo-2-nitrotoluene | HCID 77569 | — |
| 반응물 | Tert-butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate | HCID 46785870 | — |
| 반응물 | Tert-butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperidine-1-carboxylate | HCID 59732041 | — |
| 생성물 | tert-Butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperazine-1-carboxylate | HCID 59732018 | 51% |
반응 단계
tert-Butyl 4-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate (1.0 g, 3.9 mmol) and 2-nitrobenzylbromide (1.0 g, 4.6 mmol) were reacted in a manner analogous to the preparation of tert-butyl 4-(1-methoxy-3-(2-nitrophenyl)-1-oxopropan-2-yl)piperidine-1-carboxylate. Title compound was obtained as amber oil in 51% yield. MS m/e (M+H)+≦394.4.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384931B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-d6f7b4405e7d40b1b24dae4f02077d39 |
| 출처 메모 | uspto-grants-2008_06 |