3-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one → 2-(Piperidin-4-yl)-1,2-dihydroisoquinolin-3(4H)-one

Participants

Role	Name	HCID	Charge
Reactant	3-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one	HCID 18321246	—
Reactant	tert-Butyl 4-(3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate	HCID 59731897	—
Product	2-(Piperidin-4-yl)-1,2-dihydroisoquinolin-3(4H)-one	HCID 59731888	96%

Reaction Steps

tert-Butyl 4-(3-oxo-3,4-dihydroisoquinolin-2(1H)-yl)piperidine-1-carboxylate (730 mg, 2.2 mmol) was reacted in a manner analogous to the preparation of 3-(piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one. Title compound was obtained as yellow solid in 96% yield. MS m/e (M+H)+=231.4.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07384931B2
Source dataset	uspto-grants-2008_06
ORD ID	ord-39397c5f9cde45f2818119ce5aee1e88
Source note	uspto-grants-2008_06