反应详情

(S)-Dimethyl 2-((7-chloro-4-(hydroxymethyl)-1H-indazol-5-yl)methyl)succinate (2.0 g, 5.9 mmol) was dissolved in dichloromethane (35 mL). Thionyl chloride (5.0 mL) was added to the mixture. Reaction stirred at room temperature for 1.5 hours. Mixture was concentrated. Residue was dissolved in ethyl acetate. Mixture was washed twice with aqueous sodium bicarbonate and once with brine. Organic was dried (magnesium sulfate), filtered and concentrated in vacuo. Title compound was obtained as amber solid in 89% yield. MS m/e (M+H)+=359.1.

1. customReaction
2. concentrationMixture was concentrated
3. dissolutionResidue was dissolved in ethyl acetate
4. washMixture was washed twice with aqueous sodium bicarbonate and once with brine
5. dry with materialOrganic was dried (magnesium sulfate)
6. filtrationfiltered
7. concentrationconcentrated in vacuo