Pyridine → HCID 178432494, compound

Participants

Reaction Conditions

Reaction Steps

0.3 ml of acetic anhydride was added to a pyridine (0.5 ml) solution of 20 mg of 5-(2-(N-hydroxycarbaminidoyl)-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole obtained in the same manner as in Example 61 but using 5-(2-cyano-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole obtained in Example 5, and the reaction liquid was stirred overnight at 60° C. The solvent was evaporated away under reduced pressure, and this was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=10/1) to obtain the entitled compound as a pale yellow solid.

Provenance & Evidence