HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1324850Generated: October 31, 2026
Morpholine → 4-(3-(Trifluoromethyl)phenyl)morpholine
https://huagongshe.com/reaction/1324850
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-iodo-4-(trifluoromethyl)- | HCID 67993 | — |
| Reagent | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | copper(I) bromide | HCID 24593 | — |
| Catalyst | N'-benzyl-N-(2-methylnaphthalen-1-yl)ethanediamide | HCID 126500423 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 4.213% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 9.096% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-3c8e0f16b49a48a2b728787d67dcd1ca |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
