1,3-Thiazole-2-carbaldehyde → 4-(2-Methoxy-phenoxy)-6-(pyridin-3-yloxy)-2-thiazol-2-yl-1H-benzimidazole

HRID 13249Notes

Reaction equation

HRID 13249 reaction equation
[CH3:1][O:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[O:5][C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH:9]=[C:8]([NH2:19])[C:7]=1[NH2:20].[S:25]1[CH:29]=[CH:28][N:27]=[C:26]1[CH:30]=O>>[CH3:1][O:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[O:5][C:6]1[C:7]2[N:20]=[C:30]([C:26]3[S:25][CH:29]=[CH:28][N:27]=3)[NH:19][C:8]=2[CH:9]=[C:10]([O:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 27349031,3-Thiazole-2-carbaldehydeHCID 231457673-(2-Methoxyphenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine

Product 1

HCID 231458004-(2-Methoxy-phenoxy)-6-(pyridin-3-yloxy)-2-thiazol-2-yl-1H-benzimidazole

Procedure

The entitled compound was obtained as a yellow solid in the same method as in Example 67 or in accordance with the method or by combining it with an ordinary method but using 3-(2-methoxyphenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 67 (step 3) and 2-thiazolecarboxaldehyde.

Workup

  1. customThe entitled compound was obtained as a yellow solid in the same method as in Example 67 or in accordance with the method

Sources & evidence

ORD record
ord-6081390c99d14e3e9803f69cfd4d22cc
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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