HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 136082894, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoate | HCID 11961458 | — |
| Reactant | 5,5-Dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride | HCID 23466245 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 136082894 | HCID 136082894 | — |
Reaction Steps
A mixture containing 5.15 g (26.52 mmol) of ethyl 3-(4-pyrimidinyl)-3-oxopropionate, (prepared by analogy to the method described in patent DE 2705582), 4.34 g (26.52 mmol) of 5,5-dimethyl-1,4,5,6-tetrahydro-2-pyrimidinamine monohydrochloride (prepared by analogy to U.S. Pat. No. 4,262,122) and 3.66 g (26.5 mmol) of potassium carbonate in 60 ml of methanol were heated at reflux temperature during 18 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388005B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-211ad324d0b44af194c598785deb698e |
| Source note | uspto-grants-2008_06 |