Tetra-methoxypropane → HCID 23145300, compound

HRID 13252Notes

Reaction equation

HRID 13252 reaction equation
CO[CH:3]([CH3:11])[C:4](OC)(OC)OC.[F:12][C:13]1[CH:37]=[CH:36][C:16]([O:17][C:18]2[C:26]3[N:25]=[C:24]([NH:27][NH2:28])[NH:23][C:22]=3[CH:21]=[C:20]([O:29][C:30]3[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=3)[CH:19]=2)=[CH:15][CH:14]=1>C(O)C>[F:12][C:13]1[CH:37]=[CH:36][C:16]([O:17][C:18]2[C:26]3[N:25]=[C:24]([N:27]4[CH:11]=[CH:3][CH:4]=[N:28]4)[NH:23][C:22]=3[CH:21]=[C:20]([O:29][C:30]3[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=3)[CH:19]=2)=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 21988363Tetra-methoxypropaneHCID 23145521(4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazol-2-yl)-hydrazine

Product 1

HCID 23145300HCID 23145300, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

0.012 ml of tetramethoxypropane was added to an ethanol (0.3 ml) solution of 8.3 mg of (4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazol-2-yl)-hydrazine, and the reaction liquid was stirred overnight at 80° C. The reaction solvent was evaporated away under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=9/1) to obtain the entitled compound.

Workup

  1. customthe reaction liquid
  2. customThe reaction solvent was evaporated away under reduced pressure
  3. customthe resulting residue was purified
  4. customthrough partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=9/1)
  5. customto obtain the entitled compound

Sources & evidence

ORD record
ord-f181fed512bf408a8e01af2e61192eec
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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