HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzhydryl-2-methyl-1H-indol-7-yl-ether → 2-methyl-1H-indol-7-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzhydryl-2-methyl-1H-indol-7-yl-ether | HCID 69197050 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-methyl-1H-indol-7-ol | HCID 18765222 | 50.1% |
Reaction Steps
Benzhydryl-2-methyl-1H-indol-7-yl-ether (85 mg, 0.271 mmol) in methanol (MeOH) (3 mL) and toluene (3 mL) was hydrogenated in the presence of 20% palladium hydroxide (Pd(OH)2) (40 mg) at 40 p.s.i for 70 min at room temperature. The catalyst was filtered off, filtrate concentrated and the residue purified by silica gel flash chromatography to give subtitled compound (20 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388020B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-3988c418b5d546f7bfa026cb218613d3 |
| Source note | uspto-grants-2008_06 |