Nitric Acid → 4,5-Difluoro-2-nitrophenol

Participants

Reaction Steps

3,4-Difluorophenol (3.10 g, 23.7 mmole) was dissolved in acetic acid (15 ml). To the stirred solution was added dropwise a solution of fuming nitric acid (HNO3) (1.25 g, 29.7 mmole) in acetic acid (6 ml). The temperature was kept under 50° C. during the entire addition. After completed addition, the mixture was stirred for another hour. The reaction mixture was poured onto ice-water, giving precipitation of a yellowish solid.

Provenance & Evidence