Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-(3-(1-Hydroxycyclopent-3-enyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea → HCID 68527407, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-(3-(1-Hydroxycyclopent-3-enyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea | HCID 68527883 | — |
| 반응물 | 1-(2-(3-(4-Hydroxyhepta-1,6-dien-4-yl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea | HCID 68529786 | — |
| 촉매 | (1,3-Dimesitylimidazolidin-2-ylidene)(tricyclohexylphosphine)benzylidene ruthenium dichloride | HCID 11147261 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 68527407 | HCID 68527407 | — |
반응 단계
1-(2-(3-(1-hydroxycyclopent-3-enyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea: A mixture of Example 640 (125 mg, 0.25 mmol) and Grubb's second generation catalyst (0.6 mg) in dichloromethane (70 mL) was stirred at rt for 16 h. An additional 1.0 mg of Grubb's second generation catalyst was added and the mixture was stirred at rt for an additional 17 h. Evaporation under reduced pressure afforded a residue which was filtered and purified using reverse-phase preparative HPLC. (M+H)+=472.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07388021B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-4f0a761f324e433fad2366a03414ca74 |
| 출처 메모 | uspto-grants-2008_06 |