化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 5-Acetyl-1,3-benzoxazol-2(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Triphosgene | HCID 94429 | — |
| 反応物 | 3'-Amino-4'-hydroxyacetophenone | HCID 13724142 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-Acetyl-1,3-benzoxazol-2(3H)-one | HCID 15113571 | — |
反応手順
7.8 ml of triethylamine and 2.75 g (0.0093 mol) of triphosgene are added to a mixture of 4.2 g (0.0277 mol) of 2-amino-4-methylcarbonylphenol in 100 ml of THF, at 0° C. The mixture is stirred at room temperature for 1 hour, poured into 100 ml of a 0.5N HCl solution and extracted with ethyl acetate, the organic phase is dried and the solvent is evaporated off. The compound of the title is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07388031B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-4bcf49dca56c44ff98bc5112ba8c17d6 |
| 出典メモ | uspto-grants-2008_06 |